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Rapidpoint Coag Ecarin Clotting Time (ECT)
Prothrombin Time (PT)

Fibrinolysis
activated Partial Thromboplastin Time (aPTT)

ENOX
Heparin Management Test (HMT)

Low Heparin Management Test (LHMT)
  1. Oberhardt, B.J., Taylor, M., Alkadhi, Z.Y., and Dermott, S.C. Diagnostic Assay System for Convenient Monitoring of Oral Anticoagulant Therapy. Presented at the XIIth Congress of the International Society on Thrombosis and Haemostasis, Tokyo, Japan, 1989. Thrombosis and Haemostasis, 62 (1) 327a, 1989.
  2. Dermott, S.C. and Oberhardt, B.J. Real Time Monitoring of the Effect of Platelets on the Activated Partial Thromboplastin Time of Citrated Blood Containing Heparin. Presented at the 23rd Congress of the International Society of Hematology, Boston, Mass., 1990. Blood, 76 (10) Suppl. 1, 419a, 1990.
  3. Rose, V.L., Dermott, S.C., Murray, B., McIver, M., High, K.A., and Oberhardt, B.J. Decentralized Testing for PT and Activated PTT: Early Experiences with a Dry Chemistry Portable Analyzer. Presented at the 23rd Congress of the International Society of Hematology, Boston, Mass., 1990. Blood, 76 (10) Suppl. 1, 436a, 1990.
  4. Oberhardt, B.J., Dermott, S.C., Taylor, M., Alkadi, Z.Y., and Gresalfi, N. Dry Reagent Technology for Rapid, Convenient Blood Coagulation and Fibrinolysis Measurements. Presented at the 10th International Congress on Fibrinolysis, Indianapolis, Indiana, 1990. Fibrinolysis, (4) Suppl. 3, 35, 1990.
  5. Abruzzini, A.F., Edelberg, J.M., Pizzo, S.V., Alkadi, Z., Gresalfi, N.J., O'Mara, L., and Oberhardt, B.J. High Concentrations of Human Lipoprotein (a) Interfere with rt-PA-Induced Fibrinolysis when Incorporated into the Clot Matrix. Presented at the 10th International Congress on Fibrinolysis, Indianapolis, Indiana, 1990. Fibrinolysis, (4) Suppl. 3, 77, 1990.
  6. Sane, D.C., Gresalfi, N.J., O'Mara, L., Califf, R.M., Greenberg, C.S., Bovill, E., and Oberhardt, B.J. A Rapid New Method for the Assessment of Coagulation and Fibrinolysis Parameters During Thrombolytic Therapy. Presented at the 10th International Congress on Fibrinolysis, Indianapolis, Indiana, 1990. Fibrinolysis, (4) Suppl. 3, 36, 1990.
  7. Oberhardt, B.J., Dermott, S.C., Taylor, M., Alkadi, Z.Y., Abruzzini, A.F., and Gresalfi, N.J. Dry Reagent Technology for Rapid, Convenient Measurements of Blood Coagulation and Fibrinolysis. Clinical Chemistry, 37 (4), 520, 1991.
  8. Oberhardt, B.J., Gresalfi, N.J., Enney-O'Mara, L.A., Bingham, W.H., Taylor, M., and Abruzzini, A.F. Measurement of Functional Activity of Thrombolytic Drugs Using Lysis Onset Time, a Quantitative Parameter Based on Analysis of Motion of Paramagnetic Particles in a Thrombus. Presented at the XIIIth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, 1991. Thrombosis and Haemostasis, 65 (6) 2062a, 1991.
  9. Musselman, D.R., Tate, D.A., Oberhardt, B.J., Abruzzini, A.E., and Dehmer, G.J. Comparison of In Vitro Sensitivity to Thrombolysis with Three Thrombolytic Agents by Analysis of Paramagnetic Particle Motion in Clot in an Oscillating Magnetic Field. Presented at the XIIIth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, 1991. Thrombosis and Haemostasis, 65 (6) 150a, 1991.
  10. Musselman, D.R., Dehmer, G.J., Oberhardt, B.J., Abruzzini, A.F., and Tate, D.A. Sensitivity to In Vitro Thrombolysis with Tissue Plasminogen Activator Analyzed by Motion of Paramagnetic Particles Entrapped in Clot in an Oscillating Magnetic Field. Presented at the XIIIth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, 1991. Thrombosis and Haemostasis, 65 (6) 1770a, 1991.
  11. Musselman, D.R., Tate, D.A., Oberhardt, B.J., Abruzzini, A.F., and Dehmer, G.J. Gender Differences in Sensitivity to In Vitro Thrombolysis With Tissue Plasminogen Activator. Presented at the 64th Scientific Sessions of the American Heart Association, Anaheim, California, 1991. Supplement to Circulation, 84 (4) 2378, 1991.
  12. Musselman, D.R., Tate, D.A., Oberhardt, B.J., Abruzzini, A.F., and Dehmer, G.J. Differential Sensitivity to In Vitro Thrombolysis With 3 Drugs Detected by Motion Analysis of Paramagnetic Particles Within a Clot in an Oscillating Magnetic Field. Presented at the 64th Scientific Sessions of the American Heart Association, Anaheim, California, 1991. Supplement to Circulation, 84 (4) 1862, 1991.
  13. Sane, D.C., Gresalfi, N.J., Enney-O'Mara, L.A., Califf, R.M., Greenberg, C.S., Bovill, E.G., and Oberhardt, B.J. Exploration of Rapid Bedside Monitoring of Coagulation and Fibrinolysis Parameters During Thrombolytic Therapy. Blood Coagulation and Fibrinolysis, 3, 47, 1992.
  14. Cohen, J.A., Charles, L., Wason, T.D., Dermott, S.C., and Macik, B.G. Delay in Sample Processing May Significantly Decrease Whole Blood and Plasma APTTs Obtained from Heparinized Patients Resulting in Establishment of Erroneous Therapeutic Whole Blood APTT Ranges. Presented at the 34th Annual Meeting of the American Society of Hematology, Anaheim, California. Blood, 80 (10) Suppl 1, #1943, 1992.
  15. Rose, V.L., Dermott, S.C., Murray, B.F., McIver, M.M., High, K.A., and Oberhardt, B.J. Decentralized Testing for PT and Activated PTT Using a Dry Chemistry Portable Analyzer. Archives of Pathology & Laboratory Medicine, 117, 611, 1993.
  16. Wilson, S.G., Hoppensteadt, D., Walenga, J.M., Fareed, J., and Oberhardt, B.J. A Dry Chemistry APTT Method for Rapidly Monitoring Blood Levels of Hirudin and Other Thrombin Inhibitors. Presented at the XIVth Congress of the International Society on Thrombosis and Haemostasis, New York, NY, 1993. Thrombosis and Haemostasis, 69 (6), 661, 1993.
  17. Alkadhi, Z.Y., Crowder, P.F., Ernst, P.S., Taylor, M., and Oberhardt, B.J. Convenient Dry ChemistrySystem for Rapid Fibrinogen Determination. Presented at the XIVth Congress of the InternationalSociety on Thrombosis and Haemostasis, New York, NY, 1993. Thrombosis and Haemostasis, 69 (6), 835, 1993.
  18. Oberhardt, B.J., Ernst, P.S., and Alkadhi, Z.Y. Measuring Fibrinogen from Finger Stick Samples Using a Dry Chemistry Based System. Presented at the XIVth Congress of the International Society on Thrombosis and Haemostasis, New York, NY, 1993. Thrombosis and Haemostasis, 69 (6), 1082, 1993.
  19. Oberhardt, B.J., Gresalfi, N.J., Fearrington, T., Goslen, G., Turpie, A.G., and Massel, D. Rapid Determination of Resistance to SK in Thrombolytic Therapy Patients Using a Simple In Vitro Dry Chemistry Test. Presented at the XIVth Congress of the International Society on Thrombosis and Haemostasis, New York, NY, 1993. Thrombosis and Haemostasis, 69 (6), 1654, 1993.
  20. Wilson, S.G., Dermott, S.C., Gresalfi, N.J., and Pritchard, C.G. Use of a Prototype, Rapid, Dry Chemistry System to Monitor Activated Partial Thromboplastin Times. Presented at the 45th National Meeting of the American Association for Clinical Chemistry, New York, NY, 1993. Clinical Chemistry, 39 (6),1131, 1993.
  21. Oberhardt, B.J. Lysis Onset Time: A Convenient, Quantitative, Global Fibrinolysis Measurement. Blood Coagulation and Fibrinolysis, 5 (4), 1993.
  22. Daly, D.P., Tate, D.A., Gresalfi, N.J., Oberhardt, B.J., and Dehmer, G.J. Impaired Responses to In Vitro Thrombolysis Induced by Radiographic Contrast Agents. Presented at the 42nd Annual Scientific Session of the American College of Cardiology, Anaheim, CA, 1993. Journal of American College of Cardiology, 21, Suppl. A, 396A, 1993.
  23. Oberhardt, B.J. Advancing Blood Coagulation Testing to the Point of Care in Response to Molecular
    Biology Driven Development of Pharmaceuticals. Clinical Chemistry, 39 (9), 1982, 1993.
  24. Massel, D., Turpie, A.G., Oberhardt, B.J., Gresalfi, N.J., Fearrington, T., and Goslen, G. Estimation of Resistance to Streptokinase: A Preliminary Report of a Rapid Bedside Test. Presented at the 66th Scientific Session of the American Heart Association, Atlanta, GA, 1993. Supplement to Circulation, 88 (4) I-154, 1993.
  25. Leumas, J.B., and Macik, B.G. Case of the Month: Point of Care Testing in Coagulation. Clinical Hemostasis Review, January, 1994.
  26. Musselman, D.R., Tate, D.A., Oberhardt, B.J., Abruzzini, A.F., Blauwet M.B., Koch G., and Dehmer, G.J. Differences in Clot Lysis Among Patients Demonstrated In Vitro with Three Thrombolytic Agents (Tissue-type Plasminogen Activator, Streptokinase and Urokinase). American Journal of Cardiology,73, 544, 1994.
  27. Oberhardt, B.J., Dermott, S., Wilson, S.G., and Ernst, P.S. Progress In The Development Of A Rapid, Dry Chemistry, Whole Blood Fibrinogen Assay System. Submitted to the 2nd International Symposium on Fibrinogen and Cardiovascular Disease, Edinburgh, Scotland, November, 1994. Supplement to Blood Coagulation and Fibrinolysis, 5 (Suppl.2) 2, 1994.
  28. Wilson, S.G., Ernst, P.S., and Cole, C.B. Characterization of a New Method for Near-Patient Monitoring of Heparin Therapy. Presented at the 36th Annual Meeting of the American Society of Hematology, Nashville, Tennessee. Blood, 84 (10) Suppl 1, #264, 1994.
  29. Hung, A., Walker, I.D., McCall, F., Kinsella, E., and Conkie, J.A. Evaluation of a New Dry ChemistrySystem for Routine Coagulation Testing. British Journal of Haematology: 89: (supplement 1), 30.1995.
  30. Oberhardt, B.J., Gresalfi, N.J., Tabares, A., Pritchard, C., and Lord, S.T. Detecting Impaired Fibrinolysis in Plasma Samples with Abnormal Fibrinogens Using a Rapid, Dry Chemistry Method. Presented at the XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, 1995. Thrombosis and Haemostasis, 73 (6), 1145, 1995.
  31. Bailay, A., Conard, J., and Horellou, M. Rapid PT and aPTT Evaluation on Citrated Whole Blood or Plasma Using Test Cards and a Portable Instrument. Presented at the XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, 1995. Thrombosis and Haemostasis, 73 (6), 1237, 1995.
  32. Brace, L.D. Comparison of the ACT and HMT Tests for Monitoring Heparin Therapy in the Cardiopulmonary Bypass Suite. Presented at the XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, 1995. Thrombosis and Haemostasis, 73 (6), 939a, 1995.
  33. Mollerup, H.M., Landorph, A., Videbaek, J., and Nielsen, J.D. Occurrence of Hypotension During Thrombolytic Therapy for Myocardial Infarction. Presented at the XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, 1995. Thrombosis and Haemostasis, 73 (6), 1431, 1995.
  34. Owings, J.T., Pollock, M.E. Gosselin, R.C. and Ireland, K. Heparin Management Test; an Improved Method of Assessing Anticoagulation During Cardiopulmonary Bypass in the Pediatric Population. Presented at the XVth Congress of the International Society on Thrombosis and Haemostasis, Jerusalem, Israel, 1995. Thrombosis and Haemostasis, 73 (6), 976, 1995.
  35. Wilson, S.G., Hayward, K., Slauthger, T.F. Evaluation of a New Point-Of-Care Test For Monitoring Intermediate to Low Ranges of Heparin Therapy.
  36. Merenbloom, B.K. and Oberhardt, B.J.: Homogeneous Immunoassay of Whole-Blood Samples. Clinical Chemistry, 41 (9) 1385, 1995.
  37. Oberhardt, B.J. Thrombosis and Hemostasis Testing at the Point Of Care. American Journal of Clinical Pathology, (Pathology Patterns) 104, No. 4, (Suppl.1), S72, 1995.
  38. Macik, B.G., Designing a Point of Care Program for Coagulation Testing. Archives of Pathology and Laboratory Medicine, 104, 1995.
  39. Iqbal, O., Mize, P., Oberhardt, B., Jeske, W., Hoppensteadt, D., and Fareed, J. Rapid Point of Care Monitoring of Antithrombin Agents Using a Newly Developed Paramagnetic Iron Oxide Test Card Based Technology. Blood 86 (10) Supp 1, #3485, 1995
  40. Tripodi, A., Clerici, M. Negri, B. Chantarangkul, V., and Mannucci, P.M. International Sensitivity Index (ISI) Determination for a New Very Sensitive Point of Care Testing Device to Monitor Oral Anticoagulant Therapy. Assessment of Adequacy to the Recommended W.H.O. Model. Blood 86 (10) Suppl 1, #3546, 1995.
  41. Oberhardt, B.J., Rapid, Point-of-Care Monitoring of Anticoagulants. Chapter 8.4 (pp. 8.4.1 - 8.4.19) Advances in Anticoagulant, Antithrombotic & Thrombolytic Therapies. Ed., Zavoico G. International Business Communications, Inc. Southborough, MA. 1996.
  42. Jørgensen, B., Stoffersen, E., Toeboell, P., and Bulow, R. Comparison of Two Automated Whole-blood Coagulaometers for assessment of Clotting Times During Coronary Bypass Surgery. Blood Coagulation and Fibrinolysis: 7, 406. 1996
  43. Kitchen, S. and Preston, F.E. Monitoring Oral Anticoagulant therapy with the TAS Near Patient Test System: Comparison with Conventional Thromboplastins. British Journal of Haematology: 93(supplement 1), 89. 1996
  44. McGregor, J.E., Pirie, G., Adakha, S., Davey,P.G., Goudie, G.M., and Cachia, P.G. Near Patient INR Testing and Warfarin Dosing by Nursing Staff in General Practice. British Journal of Haematology: 93(supplement 1) 89. 1996
  45. Jørgensen, B., Stoffersen, E., Toelboell, P., and Bulow, R. Comparison of Two Automated Whole-blood Coagulometers for Assessment of Clotting Times during Coronary Bypass Surgery. Fibrinolysis: 10 (s3), 98. 1996.
  46. Jørgensen, B., Stoffersen, E., and Bulow, R. High Analytic Precision of an Automated Whole-blood Coagulometer for INR Monitoring During Oral Anticoagulant Therapy. Fibrinolysis: 10 (S3), 99. 1996.
  47. Toelboell, P., Bulow, R., Stoffersen, E. and Jørgensen, B. Comparison of Two Automated Whole-blood Coagulaometers for Assessment of Clotting Times During Coronary Bypass Surgery. Scandinavian Journal of Thoracic Cardiovascular Surgery: S44, 82. 1996.
  48. Bhargava, B., Holme, E., Birnie, D., Hood, S., Swan, L., MacIntyre, P. and Hillis, W.S. Measurement of Streptokinase Antibodies or Inhibitors in Blood: Comparison of a Rapid Desk Top Panel as Conventional Antibody and Resistance Assays. European Heart Journal: 17 (abstract supplement), 203. 1996.
  49. Al Swafi, K., Col, J., and Renkin, J. Rapid Screening for Streptokinase Resistance Using a New Bedside Test. European Heart Journal: 17 (abstract supplement), 203. 1996.
  50. Jørgensen, B., Bulow, R. and Stoffersen, E. High Analytic Precision of an Automated Whole-blood Coagulaometer for Monitoring Oral Anticoagulant Therapy. Haemostasis: 26, (S3), A329. 1996.
  51. Jørgensen, B., Toelboell, P., Stoffersen, E., and Bulow, R. Comparison of Two Automated Whole-blood Coagulometer for Monitoring Clotting Times During Coronary Bypass Surgery. Haemostasis: 26, (S3), A329. 1996.
  52. Jørgensen, B., Bulow, R. and Stoffersen, E. Evaluation of a New Whole-blood Coagulometer for Bedside Monitoring of APTT. Haemostasis: 26, (S3), A 330. 1996.
  53. Slaughter, T.T., Grocott, H., Greenblo, K., Bennett-Guerrero, E., Hilton, A., Hodgins, L., Mark, J.B., The Heparin Management Test (HMT): An Improved Method for Monitoring Anticoagulation During Cardiac Surgery. Anesthesia, 1996
  54. Linder R., Grip L., Olason E., and Blombäck M. Bedside Heparin Monitoring by Activated Partial Thromboplastin Time Measured with a Dry Reagent. Clin Chem 42 (9). 1488, 1996.
  55. Mertzlufft, F., Risch, A., and Seyfert, U.T. Der TAS Analyzer. Anaesthesist: 46, 233. 1997.
  56. Gibbs, N.M., Weightman, W.M., Thackray, N. M., Michalopoulos, N., An Evaluation of the TAS Heparin Management Test in Cardiac Surgical Patients in Vitro and in Vivo. Anesthesia and Analgesia, Feb. 1997
  57. Jennings, I. Kitchen, S., Woods, T.A., and Preston, F.E. External Quality Assessment of Near Patient Testing Devices in Blood Coagulation. British Journal of Haematology: 97 (supplement 1), 67. 1997.
  58. Gardiner, C., Mackie, I.J., Grant, D., Chitolie, A., and Machin, S.J. Evaluation of Near Patient Testing Devices to Measure Prothrombin Time and INR. British Journal of Haematology: 97 (supplement 1), 68. 1997.
  59. Risch, A., Bergum, G., Speigel, J., Biedler, A., Seyfert, U.T., Mertzlufft, F. Heparin-sensitivity of point-of-care aPTT testing during femuropopliteal bypass grafting: Laboratory based system vs. "TAS-analyzer". European Society of Anesthesiologists Congress. May 1997
  60. Moncada, R., Iqbal, O., Ero, M., Hoppensteadt, D., and Fareed, J. Anticoagulant Drug Interactions with Contrast Media. Thrombosis and Haemostasis: (supplement), 297. 1997.
  61. Calls, D., Iqbal, O., Rangel, Y., Lewis, B.E., Mize, P.D., and Hoppensteadt, D. Monitoring of Antithrombin Drugs Using Ecarin Clotting Time. Comparison of Dry-chemistry and Liquid Reagent. Thrombosis and Haemostasis: (supplement), 301. 1997.
  62. Mize, P.D., and Ruebsaman, K. Dry-chemistry Ecarin Clotting Time for ex vivo Monitoring of Thrombin Inhibitors. Thrombosis and Haemostasis: (supplement), 436. 1997.
  63. Lewis, B.E., Iqbal, O., Hoppensteadt, D., Ahsan, A., Ahmad, S., Messmore, H.L., Schwarz, R.P., Walenga, J.M. Clinical pharmacokinetic and pharmacodynamic studies on Argatroban to optimize the anticoagulant dosage in Interventional Cardiovascular Procedures. Thrombosis and Haemostasis: (supplement), 492. 1997.
  64. Iqbal, O., Lewis, B.E., Rangel, Y., Schwarz,. R., and Walenga, J.M. Monitoring the Anticoagulant Effects of Argatroban During Coronary Angioplasty and Stenting Using a Point of Care Dry Reagent Test Card System and its Comparison with ACT (Hemotec and Hemochron). Thrombosis and Haemostasis: (supplement), 494. 1997.
  65. Al Shwafi, K., Col, J., Pirenne, B., de Meester, A., Miesse, C., and Renkin, J. Lytic Activity with Accelerated tPA Assessed at Bedside During Thrombolytic Therapy for Acute Myocardial Infarction. Thrombosis and Haemostasis: (supplement), 502. 1997.
  66. Losco, P., Konda, M.T., Coad, C., Richard, K.A., and Joshua, D.E. Evaluation of Two Near Patient Testing Instruments at RPAH Anticoagulant Clinic. Thrombosis and Haemostasis: (supplement), 699. 1997.
  67. Jennings, I., Kitchen, S., Woods, T.A., and Preston, F.E. External Quality Assessment of Near Patient Testing Devices in Blood Coagulation. Thrombosis and Haemostasis: (supplement), 704. 1997.
  68. Tripodi, A., Chantarangkul, V., Clerici, M., Negri, B., and Mannucci, P.M. Overview on the Assessment of Conformity to the Calibration Model and its Application to the Calibration of a Sensitive Near-patient testing Device to Monitor Oral Anticoagulant Therapy. Thrombosis and Haemostasis: (supplement), 762. 1997.
  69. Jørgensen, B., Bulow, R., Tolboll, P., and Stoffersen, E. A Whole-blood Analyzer (TAS) Superior to Activated Clotting Time (ACT) in Monitoring Heparin During and After Coronary Bypass Surgery. Thrombosis and Haemostasis: (supplement), 764. 1997.
  70. Brosstad, F., Flom-Halvorsen, H. and Bjornsen. Comparison of Two Different Methods (ACT versus TAS) for Determination of Heparin Concentration in Blood During Cardio-pulmonary Bypass. Thrombosis and Haemostasis: (supplement), 764. 1997.
  71. Tripodi, A., Chantarangkul, V., Clerici, M., Negri, B. and Mannucci, P.M. Determination of the International Sensitivity Index of a New Near-Patient Testing Device to Monitor Oral Anticoagulant Therapy. Thrombosis and Haemostasis: 78, 855. 1997.
  72. Col, J., Al Shwafi, K., Pirenne, B., de Meester, A., Miesse, C., and Renkin, J. Lytic Activity Profile of 1.5 MU Streptokinase Infused in 60 Minutes for Acute Myocardial Infarction. European Heart Journal: (supplement), in press. 1997.
  73. de Meester, A., Al Shwafi, K., Pirenne, B., Miesse, C., Renkin, J. and Col, J. Comparison of Lytic Activities during Accelerated tPA and Streptokinase Infusion in Patients Treated for Acute Myocardial Infarction. European Heart Journal: (supplement), in press. 1997
  74. Al Shwafi, K., de Meester, B., Pirenne, B., Miesse, C., Renkin, J. and Col, J. Comparative Lytic Activity Profiles of Accelerated Infusion of tPA and 30 mg Bolus of TNK-tPA. European Heart Journal: (supplement), in press. 1997.
  75. Oberhardt, B.J., Mize, P. D., Pritchard, C. G., Point-of-Care Fibrinolytic Tests: The Other Side of Blood Coagulation. Clinical Chemistry: 43:9, 1697-1702, 1997.
  76. Gosselin, R.C., Owings, J.T., Larkin, E., White, R.H., Hitchinson, R., and Branch, J. Monitoring Oral Anticoagulatint Therapy with Point-of-Care Devices: Correlations and Caveats. Clinical Chemistry, 43, 9, 1785-86, 1997.

  77. Risch, A. and Mertzlufft, F., Impact of Aprotinin on ACT and HMT during CABG. Anesthesiology Analg: 86:S1-S551. 1998.
  78. Koster, A., Kuppe, H., Hetzer, R., Sodian, R. and Mertzlufft, F. On-Line Monitoring of Ecarin Clotting Time During CPB with Hirudin Due to HIT II. Anesthesiology Analg: 86:S1-S551. 1998.
  79. de Graaf, H., Maas, C. M., Ellander, S.,van Voorst tot Voorst, E.J.G.M., Edelaar, A., A Prospective Study Comparing Different Methods of Monitoring Heparin Concentration and Heparin Activity During Cardiac Surgery.
  80. Eaves, M., Kubic, V., Greeno, E., and Finnegan, A., Point-of-Care INR Testing in an Outpatient Clinic. Journal of Thrombosis and Thrombolysis Vol. 5, Supplement 1, 1998.
  81. Baker, K.R., Spann, L.H., Ortel, T.L., Monitoring Warfarin Therapy with the International Normalized Ration is Invalid in Certain Patients. Journal of Thrombosis and Thrombolysis; Vol. 5, Supplement 1, 1998.
  82. Kubic, V., Greeno, E., Eaves, M., Olson, S., Finnegan, A. Use of Prothrombin Reagent with International Sensitivity Index of 1.0 Improves Patient Management. Journal of Thrombosis and Thrombolysis: Vol. 5, Supplement 1, 1998.
  83. Greeno, E., Eaves, A., Finnegan, A., Pheley, J., Lande, G., Betterman. Improvement in Patient Communication With Point of Care Instrument in an Anticoagulation Clinic. Journal of Thrombosis and Thrombolysis; Vol. 5, Supplement 1, 1998.
  84. Mize, P., Studabaker, W., Ruebsamen, K. Near Patient Fibrinogen Assay for Monitoring Ancrod Treatment of Ischemic Stroke. Thrombolysis and Fibrinolysis, June 1998, Slovenia.
  85. Cachia, P.G., McGregor, E., Adlakha, S., Davey, P., Goudie, B.M. Accuracy and precision of the TAS analyzer for near-patient INR testing by non-pathology staff in the community. Journal of Clinical Pathology: 51:68-73, 1998.
  86. Wallock, M., Jeske, W., Walenga, J., Iqbal, O., Bakhos, M. Evaluation of a point of care anticoagulation assay: The Heparin Management Test (HMT) during cardiopulmonary bypass. American Association for Clinical Chemistry, August 1998.
  87. Iqbal, O., Ahmad, S., Hoppensteadt, D.A., Lewis, B.E., Fareed, J. Specific quantitation of thrombin inhibitors using Ecarin Clotting Time: Application in point of care testing. American Association for Clinical Chemistry, August 1998.
  88. Mize, P.D., Studabaker, W. B., Ruebsamen, K., Dempfle, C., Effects of Fibrinolysis Product on Near Patient Fibrinogen Assay for Monitoring Ancrod Treatment of Ischemic Stroke. August, 1998
  89. Mertzlufft, F., Risch, A., Koster, A., Kuppe, H., Heparin Monitoring During CPB: Comparison of Methods. Anesthesiology. 1998.
  90. Koster, A., Kuppe, H., Hetzer, R., Sodian, R., Crystal, G.J., Mertzlufft, F., Emergent Cardiopulmonary Bypass in Five Patients with Heparin-Induce Thrombocytopenia Type II Employing Recombinant Hirudin. Anesthesiology. 1998.
  91. Watke, C.M., Kern, F.H., Schulman, S.R., El-Moalom, H., Slaughter, T.F. The Heparin Management Test (HMT): An Improved Method for Monitoring Anticoagulation During Pediatric Cardiac Surgery. Anesthesiology. 1998.
  92. Helft, G., Choktron, S., Beygui, F., Le Feuvre, C., Elalamy, I., Metzger, Jean-Philippe, Vacheron, A., Comparison of Activated Clotting Times to Heparin Management Test for Adequacy of Heparin Anticoagulation in Percutaneous Transluminal Coronary Angioplasty. Catheterization and Cardiovascular Diagnosis 45: 329-331, 1998
  93. Koster, A., Kuppe, H., Mertzlufft, F. Acute HIT II During CPB. 73rd International Anesthesiology Research Society Clinical and Scientific Congress, March 1999.
  94. Mertzlufft, F., Kuppe, H., Koster, A. LMW-Heparin / Heparinoid Anti-Xa Activity Obtained by HMT (cellite, kaolin) Procedures. 73rd International Anesthesiology Research Society Clinical and Scientific Congress, March 1999.
  95. Koster, A., Kuppe, H., Mertzlufft, F. R-Hirudin Rebound After CPB in Patients with HIT (Type II). 73rd International Anesthesiology Research Society Clinical and Scientific Congress, March 1999.
  96. Mertzlufft, F., Kuppe, H., Koster, A. Acute Thrombus Formation During Hemofiltration in Cardiopulmonary Bypass with Recombinant Hirudin. Society of Cardiovascular Anesthesiologists, April 1999.
  97. Koster, A., Kuppe, H., Hetzer, R., Mertzlufft, F. Bleeding Complication Associated with R-Hirudin Application for Cardiopulmonary Bypass in Patients with Heparin-Induced Thrombocytopenia Type II. Society of Cardiovascular Anesthesiologists, April 1999.
  98. Koster, A., Kuppe, H., Mertzlufft, F. Cardiopulmonary Bypass with Recombinant Hirudin in Patients with Heparin-Induced Thrombocytopenia Type II: A Synopsis of 19 Cases. Presented 7th European Society of Anaesthesiology, May 29 - June 1, 1999, Amsterdam, the Netherlands.
  99. Fitch, Jane C.K., Geary, Kristin L.B., Mirto, Gayle P., Byrne, Daniel W., Hines, Roberta L. Heparin Management Test Versus Activated Coagulation Time During Cardiovascular Surgery: Correlation with Anti-Xa Activity. Journal of Cardiothoracic and Vascular Anesthesia, Vol. 13, No. 1 (February), 1999: PP 53-57.
  100. Mertzlufft, F., Hansen, R., Kuppe, H., Koster, A. Evaluation of the Hepcon HMT vs. Low-Molecular-Weight Heparin (LMWH) Anti-Xa Activity. British Journal of Anesthesiology, June, 1999.
  101. Gosselin, r., Owings, J., White, R., Hutchinson, R., Branch, J., Mahackian, K., Johnston, M., Larkin, E. A comparison of Point-of-Care Instruments Designed for Monitoring Oral Anticoagulation with Standard Laboratory Methods. Thrombosis and Haemostasis. 2000; 83: 698-703
  102. Koster, A., Kuppe, H., Crystal, G.J., Mertzlufft, F. Cardiovascular Surgery Without Cardiopulmonary Bypass in Patients with Heparin-Induced Thrombocytopenia Type II Using Anticoagulation with Recombinant Hirudin. Anesthesia and Analgesia, 2000; 90:292-8
  103. Mertzlufft, F., Koster, A., Kuppe, H. The Heparin Management Test: In Vitro findings for Cardiopulmonary Bypass. Anesthesia and Analgesia, Abstracts 2000; 90; S72
  104. Mertzlufft, F., Kuppe, H., Koster, A. On-Line Monitoring of r-hirudin VIA Ecarin Clotting Time: In Vitro Findings for CPB. Anesthesia and Analgesia, Abstracts 2000: 90; S72
  105. Koster, A., Hansen, R., Grauhan, O., Hausmann, H., Bauer, M., Hetzer, R., Kuppe, H., Mertzlufft, F. Hirudin Monitoring Using the TAS Ecarin Clotting Time in Patients with Heparin-Induced Thrombocytopenia Type II. Journal of Cardiathoracic and Vascular Anethesia, 2000 June; 14(3):249-52
  106. Koster, A., Kupe, H., Metzlufft, F. R-Hirudin for Cardiovascular Surgery In Patients with Hit II. 12th World Congress of Anesthesiology, June 2000
  107. Koster, A., Hansen, R., Onnen, G., Hausmann, H., Bauer, M., Hetzer, R., Kuppe, H. On-line Monitoring of Anticoagulation with Recombinant Hirudin in Patients with HIT II Using the TAS Ecarin Coltting Time: Reliability during Cardiovascular Surgery with and without Cardiopulmonary Bypass. Journal of Cardiothoracic and Vascular Anesthesia, Vol 14, No 3 (June), 2000: pp
  108. Mertzlufft, F., Koster, A., Hansen, R., Risch, A., Kuppe, H., Bernhard, K., Crystal, G. Reliability of Heparin Management Test for Monitoring High Levels of Unfractionated Heparin: In Vitro Findings in Volunteer versus In Vivo Findings during Cardiopulmonary Bypass. Anesthesiology 2000; 92: 1594-1602
  109. Koster, A., Crystal, G., Kuppe, H., Mertzlufft, F. Acute Heparin-Induced Thrombocytopenia Type II During Cardiopulmonary Bypass. Journal of Cardiothoracic and Vascular Anesthesiology, Vol 14, No 3 (2000): pp 300-303
  110. Koster, A., Hahnsen. G., Kuppe, H., hetzer, R., Crystal, G., Mertzulfft, F. Recombinant Hirudin as an Alternative for Anticoagulation During Cardiopulmonary Bypass in Patients with Heparin-Induced Thrombocytopenia Type II: A 1-Year Experience in 57 Patients. Journal of Caridiothoracic and Vascular Anesthesia, Vol 14, No. 3 (June), 2000: pp 243-248.
  111. Ambrose. T.M., Mendeloff, L., Evaluation of the TAS Analyzer and the Low Range Heparin Management Test (LHMT) in Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO). Clinical Chemistry, Supplement, 2000
  112. Owings, J. T., Pollock, M. E., Gosselin, R.C., Ireland, K., Jahr, J.S., Larkin, I.C. Anticoagulation of Children Undergoing Cardiopulmonary Bypass Is Overestimated by Current Monitoring Techniques. Archives of Surgery, Vol. 135, September 2000: pp 1042 - 1047
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  114. Al-Shwafi, KJ.A., de Meester, A., Pirenne, B., Col, J. Comparative Fibrinolytic Activity Profiles of the New Single-bolus Thrombolytics Tenecteplase and Lanoteplase During Treatment of Patients with Acute Myocardial Infarction. Presented 50th annual Scientific Session of the American College of Cardiology, March, 2001.
  115. Wallock, M., Jeski, W.P., Bakhos, M., Walenga, J.M. Evaluation of a new point of care heparin test for cardiopulmonary bypass: the TAS heparin management test. Perfusion 2001; 16: 147-153.
  116. Ambrose, T.M., Parvin, C.A., Mendeloff, E., Luchtman-Jones, L. Evaluation of the TAS Analyzer and the Low-Range Heparin Management Test in Patients Undergoing Extracorporeal Membrane Oxygenation. Clinical Chemistry, 47, No. 5, 2001
  117. Poller. L., Keown, M., van den Besselaar, A.M.H.P., Neeuwise-Braun, J., Tripodi, A., Clerici, M., Jespersen, J., Chauhan, N. European Concerted Action on Anticoagulation (ECAA) Normalsiation and Standardisation of Home Prothrombin (PT) Monitors (SMT 4-C98-2269) Certification of Plasma Calibrants for Home PT Monitors at 3 Center. Supplement Journal Thrombosis and Haemostasis, July 2001 P1426 (ISSN 0340-6245)
  118. Poller, L., Keown, M., vanden Besselaar, A.M.H.P., Meeuwisse-Braun, J., Tripodi, A., Clerici, M. ECAA Normalisation and Standardisation of Home Prothrombin (PT) Time Monitors (SMT 4-C98-2269) The Use of ECAA Calibrant Plasmas for Quality Control of Home PT Monitors-Inter Lot Variability of Test Strips/Cartridges Supplement Journal Thrombosis and Haemostasis, July 2001, P1418 (ISSN 0340-6245)
  119. Keown, M., Poller, L., van den Besselaar, A.M.H.P., Meeuwisse-Braun, J., Chauhan, N. European Concerted Action on Anticoagulation (ECAA) Normalisation and Standardisation of Home Prothrombin Time (PT) Monitors (SMT 4-C98-2269) – A Study of Inter-Instrument Variability. Journal Thrombosis and Haemostasis, July 2001, P1419 (ISSN 0340-6245)
  120. Al Shwafi, K., de Meester, A., Pirenne, B., Renkin, J., Col, J. Rapid Detection of Streptokinase Resistance using a Bedside Lytic Assay of Dry Reagent Technology. Fibrinolysis and Proteolysis (2000) 14 (6), 351-357.
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  123. Cho, L., Reginelli, J., Roffi, M., Kaldus, T., Kottke-Marchant, K., Mize, P., Moliterno, D. A New Rapid Assay, The Ecarin Clotting Time, Measure the Activity of Direct Thrombin Inhibitors in Patients Undergoing Percutaneous Coronary Intervention. AACC, Chicago, August, 2001
  124. Nichols, J. H., Kickler, T. S., Dyer, K. L., Humbertson, S. K., Cooper, P. C., Maughan, W. L., Oechsle, D. G. Clinical Outcomes of Point-Of-Care Testing in the Cardiovascular Diagnostic Setting. AACC, Chicago, August, 2001
  125. Beyer, L., Sorenson, L., Deobald, G., Newton, N., Santrach, P. Evaluation of Point Of Care Coagulation Devices for INR Testing. AACC, Chicago, August, 2001.
  126. Al Shwafi, K., Thys, F., Laterre, P.F., Jacquet, L., Goenen, M., Reynaert, M., Col, J. The Importance of Rapid Lytic Activity Assessment in Long Duration Thrombolytic Therapy. 8th World Congress of Intensive and Critical Care Medicine, Sydney, Australia, October, 2001
  127. Mize, P., Cutsforth, G., Stallings, P., Leumas, J., DeAnglis, A., Mahan, D. Development of the Rapidpoint® Coag Enoxaparin Test Card System to Monitor Lovenox® (Enoxaparin sodium) in PCI Patients. Journal of the American Society of Hematology, Blood, Vol. 98, Number 11, 2001, #185, page 46a.

  128. Mize, P., Cutsforth, G., Stallings, P., Leumas, J., DeAnglis, A., Mahan, D. Rapidpoint® Coag Enoxaparin Test: Clinical results for A POC Method for Monitoring Lovenox® (Enoxaparin Sodium) in Patients Undergoing PCI. Journal of the American Society of Hematology, Blood, Vol. 98, Number 11, 2001, #193, page 48a.
  129. Bowes III, R. C., Pritchard, C., Wilson, S. G., Col, J. Comparative Fibrinolytic Activity of Tissue Plasminogen Activator (T-PA), TNK- TPA or Desmodus Salivary Plasminogen Activator (DSPA) Using An Assay That Specifically Monitors Clot Lysis. Presented XVIIIth ISTH, Paris, 2001. Supplement Journal Thrombosis and Haemostasis, July 2001 (ISSN 0340-6245 P 435.
  130. Pritchard, C., Bowes III, R. C. Combination TNK-TPA and Abciximab with Either Heparin or Enoxaparin Does Not Alter Lysis Onset Times Using the Thrombolytic Assessment System. Supplement Journal Thrombosis and Haemostasis, July 2001 (ISSN 0340-6245), P 430.
  131. Wilson, S., Bowes III, R.C., DeAnglis, A.P., Pritchard, C. Novel Point-Of-Care Test for Monitoring the inhibition of Thrombolysis by Antifibrinolytic Agents in Whole Blood. Supplement Journal Thrombosis and Haemostasis, July 2001 (ISSN 0340-6245), P 436.

  132. Chalmers, E. A., Kasem, K., Allen, G., Rafferty, I., Davis, C. Heparin Monitoring During Paediatric Extracorporeal Membrane Oxygenation.
  133. Poller, L., Keown, M., Nikhil, C., van den Besselaar, A.M.H.P., Meeuwisse-Braun, J., Tripodi, A., Clerici, M., Jespersen, J. European Concerted Action on Anticoagulation. Use of Plasma Samples to Derive International Sensitivity Index for Whole-Blood Prothrombin Time Monitors. Clinical Chemistry, 2002;48:255-260.


    Last update – January 31, 2002

 

 

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